Membranes : CopiOs^® Pericardium

Zimmer Dental is pleased to announce the launch of the CopiOsŪ Pericardium Membrane in the United States, Europe, and Asia

Strong meets supple.

CopiOs Pericardium Membrane provides a long-lasting¹, conformable barrier that is strong² enough to meet the rigors of your clinical practice, yet also supple to adapt to challenging graft contours. Due to the ability of the Tutoplast® Process to preserve the properties of the native pericardium membrane, CopiOs Pericardium Membrane has the feel and characteristics of natural tissue – easy to manipulate and implant, drapeable and durable -- to meet your high clinical expectations. 

• Clinically-demonstrated performance in guided bone regeneration procedures^3-4, where ease of manipulation and adaptability to surface contours is essential  
• Shown to provide a stable, long-lasting barrier during healing and integration of Puros® Allografts and staged or immediately-placed implants^3-4
• Supports an aesthetic soft tissue response ^3-5 through facilitation of cell attachment and proliferation and remodeling into vascularized, connective tissue⁶
• Retains the structure and composition of natural tissue due to the proprietary Tutoplast® Process⁷, leading to optimal performance and handling^3-4

CopiOs Pericardium Membrane – Designed to work with our Puros Allograft Family of Products.
A complete line of regenerative products for every bone and soft tissue augmentation need.
Clockwise from top left: Puros Corticocancellous Block, Puros Cancellous Particles, Puros Cortical Particles, CopiOs Pericardium Membrane

The Tutoplast Process
CopiOs Pericardium Membrane is refined using the proprietary, multi-stage Tutoplast Sterilization Process. While preserving the valuable collagen matrix and tissue integrity, this process gently removes unwanted materials such as cells, antigens and viruses, as well as inactivating pathogens. Tutoplast-Processed tissues have been used for more than 35 years.

1. Osmotic treatment
2. Oxidative treatment
3. Alkaline treatment
4. Solvent dehydration
5. Limited-dose gamma irradiation

A variety of advantages

• Drapeability: supple and strong, with exceptional adaptability to surface contours
• Ease of manipulation: ease of placement and conformity to graft site
• Long-lasting barrier function: in vivo animal studies show that resorption outlasts competitive membranes¹
• Stability: multidirectional strength and tear resistance, accepts a wide range of sutures and fixation devices³
• Biocompatible: remodeled into connective tissue through normal tissue healing processes^3,6
• Tissue-friendly: seen to promote osteoblast and periodontal ligament cell proliferation in in vitro studies⁶
• History of successful clinical results across dental surgical applications^3-5
• Convenient: five-year shelf life, room temperature storage, space-saving, stackable packaging

¹Rothamel D, Schwarz F, Sager M, Herten M, Sculean A, Becker J. Biodegradation of differently cross-linked collagen membranes: an experimental study in the rat. Clin Oral Implants Res. 2005;16: 369-378.
² Data on file with RTI Biologics, Inc.
³ Kistler S, Bayer G, Kistler F, Am Lech L. Experience with the biological Tutodent® membrane in implant practice. Implantologie Zeitung Journal. 2004;8:47-48.
⁴ Simsek B, Simsek S. Evaluation of success rates of immediate and delayed implants after tooth extraction. Chinese Medical Journal. 2003;116: 1216-1219.
⁵ Steigmann M. Pericardium membrane and xenograft particulate grafting materials for horizontal alveolar ridge defects. Implant Dent. 2006;15: 186-191.
⁶ Rothamel D, Schwarz F et al. Biocompatibility of various collagen membranes in cultures of human PDL fibroblasts and human osteoblast-like cells. Clin Oral Implants Res. 2004;15: 443-449.
⁷ Schoepf C. Allograft safety: the efficacy of the Tutoplast Process. Implants: Int Magazine Oral Implant. 2006;1:10-15.

Additional references available on request.

Tutoplast is a registered trademark of RTI Biologics, Inc. CopiOs Pericardium Membrane and Puros products are manufactured for Zimmer Dental Inc. by RTI Biologics, Inc.